The coronavirus pandemic will get "worse and worse" if governments fail to take more decisive action, the World Health Organization (WHO) has warned.
Director general Dr Tedros Adhanom Ghebreyesus said "too many countries [were] headed in the wrong direction".
Cases were rising where proven measures were not adopted or followed, he added.
The Americas are the current epicentre of the pandemic. The US has seen a rise in cases amid tensions between health experts and President Donald Trump.
The US, the worst affected country, has over 3.3 million confirmed cases and more than 135,000 deaths, according to Johns Hopkins University.
At a briefing in Geneva on Monday, Dr Tedros said "mixed messages from leaders" were undermining public trust in attempts to bring the pandemic under control.
"The virus remains public enemy number one, but the actions of many governments and people do not reflect this," he said.
Dr Tedros said measures such as social distancing, hand washing, and wearing masks in appropriate situations needed to be taken seriously, warning that there would be "no return to the old normal for the foreseeable future".
"If the basics aren't followed, there is only one way this pandemic is going to go," Dr Tedros said, adding: "It's going to get worse and worse and worse."
Dr Mike Ryan, the WHO's emergencies director, said the easing of some lockdown measures in the Americas and the opening up of some areas had led to "intense transmission".
Latin America has confirmed more than 145,000 coronavirus-related deaths, though the number is believed to be higher because of insufficient testing.
Half of the deaths were in Brazil, where President Jair Bolsonaro has opposed strict measures to curb the spread of the virus.
Dr Ryan said closing down large regions would have huge economic consequences, but that local lockdowns in specific places might be necessary to mitigate the spread of the virus.
He urged governments to implement clear and "strong" strategies, adding: "Citizens have to understand, and it has to be easy for them to comply."
"We need to learn to live with this virus," Dr Ryan said, warning that expectations that the virus could be eradicated, or that an effective vaccine could be ready, within months were "unrealistic".
He said it was not yet known whether recovering from the coronavirus would lead to immunity, or, if it did, how long that immunity would last.
A separate study released on Monday by scientists at King's College London suggested that immunity to the virus may be short-lived.
Scientists at the college studied 96 people to understand how the body naturally fights off the virus by making antibodies, and how long these last in the weeks and months after recovery.
However, while almost all of those who participated had detectable antibodies that could neutralise and stop coronavirus, levels began to wane over the three months of the study.
At the WHO briefing, health experts also said there was evidence to suggest that children under the age of 10 were only very mildly affected by Covid-19, while those over 10 seemed to suffer similar mild symptoms to young adults.
To what extent children can transmit the virus, while it appears to be low, remains unknown.