纽约时报 | 曾被视为现代贵族病的偏头痛:你得知道的几件事

Why don't we know more about migraines? 曾被视为现代贵族病的偏头痛:你 […]

Why don't we know more about migraines?

The first time I experienced a migraine was one evening after school. A dull headache turned into splitting pain, blurring my vision and converting my bedroom light into a source of pure agony. Then came the vomiting. It’s a cycle I’ve experienced countless times in recent years C one that forced me to quit my job and left me feeling helpless.


A migraine attack has long been passed off as ‘just a headache’. But while ‘normal’ headaches can usually be held at bay with a paracetamol or two, a migraine is aggressive, sometimes enough to be severely debilitating. It has no conclusive cause (hormones and abnormal brain activity are just two potential reasons) or sustainable treatment on offer.


Perhaps it’s little surprise, then, that the world’s leading survey of health conditions across 195 countries found that, in every year from 1990 to 2016, migraine attacks remained the second-largest global contributor to years lived with disability. They come with a huge economic cost, too, causing an estimated 25 million sick days to be taken in the UK alone each year. But compared to their health and economic burden, migraines remain one of the world’s most under-funded diseases.


The disorder is also much more prevalent in women. In general, one in five women suffer compared to one in 15 men.


Reasons remain unclear C though a University of Arizona study of male and female rats, published in April 2018, suggests that it may be because of the link between higher oestrogen levels and lower levels of the sodium proton exchanger NHE1. Without enough NHE1, pain signalling increases. "Based on our findings, we think that women are more susceptible to migraine because the larger magnitude sex hormone fluctuations lead to changes in NHE1 expression," researcher Emily Galloway explained.

原因尚不清楚――但2018年四月发表的亚利桑那大学做的公鼠和母鼠的研究表明,可能是雌激素越多,钠氢交换蛋白NHE1越少的原因。没有足够的NHE1,疼痛信号就会增加。研究员盖洛韦(Emily Galloway)解释道,"根据我们的研究结果,我们认为偏头痛多发于女性是因为性激素的大幅波动改变了NHE1的表达。"

But when it comes to research and funding, migraines have been less investigated than other ailments. Despite the enormous economic costs, they continue to receive the least public funding of any neurological illness in Europe. In the US, where migraines affect an estimated 15% of people, the condition received $22m in research funding (£17m) in 2017. Asthma, which affects half as many people, received 13 times that amount ($286m or £218m); diabetes, affecting two-thirds as many people, received 50 times as much ($1.1bn or £84m). (Of course, it’s worth noting that asthma and diabetes are potentially life-threatening conditions).


When the condition is studied, it often is affected by a trend seen in other healthcare research: most migraine research on animals has been done on males even though women suffer from migraines more.


Given the prevalence of migraines among women, this apparent neglect could be a result of how physicians tend to underrate pain in female patients. It may also reflect the historic C and similarly gendered C associations between migraines and mental illness.


Heady history


These throbbing headaches are one of the human race’s oldest recorded ailments. Ancient Egyptian scriptures from 1200 BC detail migraine-like headaches; Hippocrates wrote about the visual disturbances and vomiting commonly associated with the disorder.


The actual discovery of migraines, however, is routinely credited to the ancient Greek doctor Aretaeus of Cappadocia, who accurately described their one-sidedness and symptom-free periods in the second century. (In fact, the word ‘migraine’ is derived from the Greek term ‘hemicrania’, meaning half skull).


Historically, the believed cause and treatment of migraines had deep superstitious links. A number of questionable treatments arose in the Middle Ages from blood-letting and witchcraft to a clove of garlic being inserted into an incision in the temple. Some medical experts recommended trepanation C the drilling of holes into the skull C as a migraine remedy. The gruesome procedure was commonly used to release evil spirits from people who were more likely to have been suffering from a mental illness than demonic possession, and is one of the first supposed links between migraines and the mind.

在历史上,人们对偏头痛的病因的认识和疗法都有浓重的迷信色彩。欧洲中世纪,出现了许多相当可疑的疗法,比如放血,还有把蒜瓣插进太阳穴的巫术等。一些医术专家推荐用头部穿孔术(trepanation )――在头骨上钻一个孔来治疗偏头痛。这种可怕的疗法常用来驱逐恶灵,实际上被治疗的人可能是精神病患者,而不是什么恶灵附体。这可能是人类最早将偏头痛与精神病联系在一起。

The greater number of females with migraines initially was noticed by doctors in the 19th Century. They believed the mind was to blame, describing the condition as a disorder of “mothers in the lower classes” whose minds were weak due to daily work, little sleep, frequent lactation and malnourishment. Women experiencing acute headaches were often ridiculed and seen as hysterical, starting the stigma of neurosis that still exists today.


“For a long time, migraine was considered a disease of modern luxury, the kind of thing that struck down intelligent upper class men and women,” says Joanna Kempner, associate professor of sociology at Rutgers University. “People with this upbringing were thought to have delicate nervous systems which enabled at least the men to engage in artistic and scientific pursuits.

罗格斯大学社会学副教授肯普纳( Joanna Kempner)说:"很长一段时间,偏头痛被视为现代贵族病,上流知识分子男女常患有偏头痛。人们认为患有偏头痛的人有着脆弱的神经系统,让他们,至少是男性,能够追求艺术或者探索科学。"

“Of course, women were believed to have a much diminished capacity for intellectual work and, as a result, could more easily overload their ‘delicate nervous systems’.”


Indeed, the father of modern headache medicine, American neurologist Harold G Wolff, defined a distinct difference between male and female migraine patients. To him, men were ambitious and successful (only getting a migraine when tired). But women had a migraine attack because they were incapable of accepting the female role, particularly when it came to sex. Wolff said his female patients accepted sex as “a reasonable marital duty, at best. In several instances, it was deemed frankly unpleasant and was resented.”

事实上,现代头痛药之父,美国神经学家沃尔夫(Harold G Wolff)即认为男性和女性偏头痛患者间有明显的差别。他认为,男性雄心勃勃,功成名就,只有感到疲倦时有偏头痛,但是女性患有偏头痛是因为她们不能接受其女性角色,特别是性生活方面。沃尔夫说他的女性病患者认为"性充其量是合理的婚姻责任,有些人直截了当地说自己不喜欢甚至讨厌性行为。"

Kempner adds: “by the end of the 20th Century, migraine became nearly synonymous with the neurotic housewife C in fact, some thesauruses even list ‘migraine’ as a synonym for ‘spouse’.”


Mind matters


It can’t be denied that there appears to be a link between the headache disorder and mental health. Several studies have concluded that migraines are commonly associated with a range of psychiatric disorders. A 2016 review found high rates of correlation between migraines and bipolar; meanwhile, people with migraines are 2.5 times more likely to develop generalised anxiety disorder (GAD), and people with depression are three times more likely to experience migraine attacks. Another study found that around one in every six migraine sufferers have seriously considered suicide at some point in their lives. (One in 10 people in the general population are said to have had suicidal thoughts.)


“But whether it is causal is a big question,” says Messoud Ashina, neurology professor and director of the Danish Headache Centre’s Human Migraine Research Unit. “When you have a very prevalent disorder like migraine, the likelihood that it can overlap with other diseases is quite high.”

阿史那(Messoud Ashina) 是神经学教授和丹麦头痛研究中心偏头痛研究部的主任,他说"到底有没有因果关系,是个大问题,因为如果患有像偏头痛这样的多发性疾病,同时患有其他疾病的概率很高。"

Of course, suffering from migraines may also lead to poor mental health C rather than a ‘delicate constitution’ leading to migraines, as Victorian physicians would have had it.


“It’s not surprising that anxiety levels are high when one is never sure when a migraine will occur and if the pain will interfere with work and family responsibilities,” points out Esme Fuller Thomson, director of the Institute for Life Course & Ageing at the University of Toronto who has researched migraine-suicide links.

汤姆森(Esme Fuller Thomson)是多伦多大学生命历程与老化研究所(Institute for Life Course & Ageing)所长,研究过偏头痛与自杀的关联,她指出:"患偏头痛的人大多都很焦虑,这并不奇怪,因为你不知道头痛什么时候会发作,会不会影响工作和家庭。"

Depression, meanwhile, also may be exacerbated by the feelings of helplessness that people with migraines often experience.


Despite the effect of migraine attacks on such a vast sum of the population, the condition is surprisingly little understood or researched. “Many people in neurology and society consider migraine as a benign disease C it is not a cancer, it is not Parkinson’s,” Ashina says. “But if you look at its public and personal impact, migraine is a huge issue.”


Amaal Starling, assistant professor of neurology at Mayo Clinic in Scottsdale, Arizona, says some specialists don’t see it as a ‘real neurology’. Headache specialists therefore have found it difficult to legitimise their practice and convince others that funding is a necessity, not a luxury.

斯塔林(Amaal Starling)是亚利桑那州斯科茨代尔梅奥医院(Mayo Clinic)的神经内科学助理教授,她说,一些专家不把偏头痛当作"真正的神经内科学疾病"。因此,头痛研究专家难以跟别人解释自己的研究是合情合理的,资助也是必要的,而不是奢侈。

And some of that difficulty in getting a predominantly ‘female’ condition taken seriously may be gender bias: in general, women have a harder time getting their pain symptoms taken seriously or getting a correct medical diagnosis than men.


Common condition


The sheer number of patients with migraines means that specialists should be well-versed in the condition, experts say. As one source that Kempner spoke with for her book Not Tonight: Migraine and the Politics of Gender and Health said: “Headache is the commonest symptom found in neurologic outpatients and the least taught to neurology residents. It’s like training electricians, but not telling them about light bulbs.”


Fortunately, a new treatment may be in the works: an injection called Erenumab, administered once a month, which works by blocking a receptor in the brain that activates a migraine attack. (A similar drug that also targets the CGRP receptor was granted approval by the US Food and Drug Administration in May 2018).

幸运的是,新的疗法可能已在用:每月注射一种叫做Erenumab单克隆抗体,能够阻碍引起偏头痛的细胞受体发挥作用,从而预防偏头痛。(美国食品和药物管理局在2018年五月批准了同样是针对降钙素基因相关肽( CGRP)细胞受体的相似药物)。

“What’s key is that this novel drug was designed for the treatment of migraine, not created for a different disease and then found to also help some people with migraine,” says Starling. “A drug designed for a disease is likely to be more effective and have less ‘off target toxicity’ which leads to reduced side effects.”


As a person currently prescribed beta blockers for migraines, I wholeheartedly agree. My medication, which is taken three times a day over the course of a few months, is intended to treat angina and high blood pressure. Doctors realised it also prevented migraines. But it wasn’t designed for migraine sufferers. And although a migraine-specific tablet is likely to also come with side effects, beta blockers have a scary-sounding list. including excessive tiredness and dizziness with the potential for a heart attack if you abruptly stop taking them.


These treatments join the likes of other modern, electrical and magnetic treatments, which involve hand-held devices sending magnetic pulses into the brain in order to alter the electrical environment of neurons and reduce ‘hyperexcitability’.


After almost six migraine-free months, I am now reducing my dose of beta blockers. My end goal? Zero medication. But another a migraine attack recently hit me. And a couple of months earlier, I was rushed to hospital with a suspected heart attack. Luckily, it was a false alarm. But it opened my eyes to the need for migraine treatment that won’t impact my vital organs. Hopefully, that invention is on the horizon.


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